Frequently Asked Questions

About KESIMPTA®

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Here are some answers

About KESIMPTA

Here’s what goes on with relapsing MS:

The immune system uses certain cells, like B cells, to help fight infections. These cells can become activated in the lymph nodes—the communication hub for the immune system.

But there’s a miscommunication that happens in relapsing MS. Instead of protecting the immune system, these cells mistakenly attack the body’s myelin—the fatty, protective covering of the nerves in the brain and spinal cord.

Here’s what KESIMPTA does:

Although it’s not known exactly how KESIMPTA works in relapsing MS, it’s thought to travel specifically to the lymph nodes based on the way it’s taken. From there, it’s thought to reduce the number of B cells that are thought to play a role in relapsing MS.

This targeted approach to the lymph nodes is thought to limit the impact on other B cells your body needs to maintain immune function.

In 2 clinical studies vs. AUBAGIO®, KESIMPTA was proven to reduce relapses and had an impact on disability progression and certain lesions.

See the study design and results here.

Talk to your doctor to find out if KESIMPTA may be right for you.

You shouldn’t take KESIMPTA if you have active hepatitis B virus (HBV) infection. Your doctor will give you a blood test before starting KESIMPTA to be sure.

KESIMPTA works by impacting your immune system, so it could increase the risk of getting serious infections, including:

  • Hepatitis B virus (HBV) reactivation: Before starting KESIMPTA, you’ll get a blood test for HBV. If you’ve ever had HBV infection, it may become active again during or after treatment with KESIMPTA.
  • Progressive multifocal leukoencephalopathy (PML): PML may happen with KESIMPTA. PML is a rare, serious brain infection caused by a virus that may get worse over days or weeks, and can result in death or severe disability.
  • Weakened immune system: Taking KESIMPTA before or after other medicines that weaken your immune system could increase your risk of getting infections.

Injection-related reactions were mostly mild to moderate. They mostly happen with the first injection, although they can happen with later injections.

  • Local injection-site reactions (redness, pain, itching, and swelling)
  • Injection-related reactions (fever, headache, muscle pain, chills, and fatigue)

Other possible side effects include:

  • Upper respiratory infections (sore throat, runny nose, and headache)
  • Headache

See more details here.

Everyone reacts to medications differently. Talk with your doctor about any possible side effects and if KESIMPTA is right for you.

Everyone reacts to treatment differently. Talk to your doctor about how KESIMPTA may work for relapsing MS. Check out the study design and results here.

It is not known if KESIMPTA passes into breast milk. Talk to your doctor about the best way to feed your baby if you take KESIMPTA.

It is not known if KESIMPTA will harm your unborn baby. Tell your doctor if you’re pregnant, think you might be pregnant, or plan to become pregnant before starting KESIMPTA.

It is not known if KESIMPTA will harm your unborn baby. Females who can become pregnant should use birth control during treatment with KESIMPTA and for 6 months after your last treatment. Talk to your doctor about what birth control method is right for you during this time.

You shouldn’t receive any live vaccines while taking KESIMPTA and until your doctor tells you that your immune system is no longer weakened. Any required live vaccines should be received at least 4 weeks before you start KESIMPTA. If possible, any “non-live” vaccines should be received at least 2 weeks before you start treatment with KESIMPTA.

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Taking KESIMPTA

You'll be screened for HBV before starting KESIMPTA because if you’ve had it in the past, there’s a chance KESIMPTA can reactivate it. You’ll get a simple blood test to be sure. 

You’ll give yourself 1 dose per week for the first 3 weeks, and then you’ll skip a week. After that, you can move on to 1 dose per month.

Someone from your health care team will give you guidance on how to take KESIMPTA with the Sensoready® Pen for the first time.

If you need a refresher on how to take KESIMPTA, you can watch an additional demo video or download some quick tips here.

You can also ask your Alongside™ KESIMPTA Coordinator to set up an additional demo—at home or online.

Call 1-855-KESIMPTA (1-855-537-4678), 8:30 am–8:00 pm ET, Monday–Friday.

If you miss an injection of KESIMPTA at Week 0, 1, or 2, talk to your doctor. If you miss a monthly injection, take it as soon as possible without waiting until the next scheduled dose. After that, take your KESIMPTA injections a month apart.

The best way is to use an FDA-cleared sharps container.

Ask your Coordinator how to get one for free. You’ll get a pre-paid return label to send your full sharps container back, and you’ll be sent a new container.

You shouldn’t throw away your Sensoready Pen in your household trash. If you don’t have an FDA-cleared sharps container, you can use a household container that is:

  • made of a heavy-duty plastic,
  • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
  • upright and stable during use,
  • leak-resistant, and
  • properly labeled to warn of hazardous waste inside the container
No, the Sensoready® Pen does not contain any latex.
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Savings & Support

Every KESIMPTA prescription for relapsing MS comes with a membership to the Alongside KESIMPTA program. Our goal is to help keep things simple and tell it like it is, so your options are always clear. You’ll work one-on-one with your dedicated Coordinator—the expert you can turn to for:

  • Coverage for treatment
  • Delivery of KESIMPTA
  • Supplemental injection training and resources
  • On-the-go resources
  • Long-term support

If you’ve been prescribed KESIMPTA, sign up here.

We’ll call you once you’re enrolled, but you can always reach us here: 1-855-KESIMPTA (1-855-537-4678), 8:30 am–8:00 pm ET, Monday–Friday.

Here’s what happens next:

  • We’ll help get you started by figuring out coverage, savings eligibility (including the $0* Access Card), and delivery
  • We’ll mail you a welcome package with some important details inside
  • You’ll get a dedicated Coordinator who will answer any questions throughout your membership

Get in touch at 1-855-KESIMPTA (1-855-537-4678), 8:30 am–8:00 pm ET, Monday–Friday. 

Yes—injection demonstrations are available. Choose from in-person demos at home, virtual demos, or this demo video.

Keep in mind these demos do not replace any instructions provided by your doctor. If you have any questions, please get in touch with your doctor.

To schedule a demo or to get a Sensoready® Training Pen, call 1-855-KESIMPTA (1-855-537-4678), 8:30 am–8:00 pm ET, Monday–Friday.

Your Alongside KESIMPTA Coordinator will identify the correct coverage assistance options to meet your needs. If you’re commercially insured and have coverage for KESIMPTA, they can enroll you in a $0 Copay Program.*

If you are not covered for KESIMPTA, Coordinators will provide additional support to your doctor so they can pursue an appeal with your health care plan.

*Access Card Program: Limitations apply. People with commercial insurance may receive up to an $18,000 annual limit and/or up to 12 months of free product while coverage is pursued. Offer not valid under Medicare, Medicaid, or any other federal or state health insurance program. See complete Terms & Conditions at start.kesimpta.com.

Medisafe™ is a free app that was designed to help keep you organized. Get support for different aspects of your treatment right from your phone or tablet.

Just search "Medisafe" in the App Store or Google Play.

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MS=multiple sclerosis.
AUBAGIO (teriflunomide), a leading oral relapsing MS treatment, is a registered trademark of Sanofi and Genzyme.
SENSOREADY is a registered trademark of Novartis AG.
Medisafe is a trademark of Medisafe Project Ltd.